Sialic Acid Metabolism and Systemic Pasteurellosis
نویسندگان
چکیده
منابع مشابه
Sialic Acid metabolism and systemic pasteurellosis.
Pasteurella multocida subsp. multocida is a commensal and opportunistic pathogen of food animals, wildlife, and pets and a zoonotic cause of human infection arising from contacts with these animals. Here, an investigation of multiple serotype A strains demonstrated the occurrence of membrane sialyltransferase. Although P. multocida lacks the genes for the two earliest steps in de novo sialic ac...
متن کاملThe terminal enzymes of sialic acid metabolism: acylneuraminate pyruvate-lyases.
The acylneuraminate pyruvate-lyase gene from Clostridium perfringens was sequenced and found to be most similar to the lyase gene from Haemophilus influenzae. Both the recombinant clostridial enzyme and the native enzyme from pig kidney were purified in larger amounts and characterized. The properties of the porcine lyase are similar to the microbial ones. However, the much higher degree of sim...
متن کاملThe role of sialic acid synthases in sialic acid biosynthesis
Introduction The sialic acids comprise a diverse family of nine-carbon keto-sugars, the majority of which are structural derivatives of neuraminic acid (Fig. 1). Neuraminic acid has an amino moiety at the C-5 position, and carboxylate at C-2 which confers negative charge at physiological pH. Whereas unsubstituted neuraminic acid is not known to exist in nature, over 40 substituted variations (c...
متن کاملSialic acid and cell aggregation.
Chick embryo neural retina cells from 7-, 10and 14-day embryos and muscle cells from 9-day embryos, dissociated mechanically or with trypsin, reaggregate at the same initial rate whether treated before and during aggregation with active or inactive iV-acetyl neuraminidase. 7V-acetyl neuraminidase treatment also has no effect on the size or number of aggregates formed over 24 or 48 h of aggregat...
متن کاملSialic acid utilization.
Early postnatal development encounters milk as a key environmental variable and yet the sole nutrient source. One evolutionary conserved constituent of milk is sialic acid, which is generally displayed on glycoconjugates and free glycans. During early postnatal development, high sialic acid need was proposed to be unmet by the endogenous sialic acid synthetic capacity. Hence, milk sialic acid w...
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ژورنال
عنوان ژورنال: Infection and Immunity
سال: 2005
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.73.3.1284-1294.2005